The Health Benefits of Chondroitin and Hyaluronic Acid for Dogs with Arthritis
The health benefits of chondroitin and hyaluronic acid that is found in chicken bone broth for dogs with arthritis is well documented. In a study done by the Animal Science Division of Oeste Paulista University, hyaluronic acid was injected into dogs with hip dysplasia. The treated group of dogs showed lower Helsinki Chronic Pain Index (HCPI) scores (a), Canine Brief Pain Inventory or pain relief scores, and in the veterinarian evaluation, compared to the Control group.
Of note, was the result that clinical improvement was observed in 100% of the animals in the Hyaluronic acid group verse only 50% in the control group (saline solution) regardless of body weight.
The fact that older dogs showed a clinical improvement including restoration of the elastic and viscous properties of the synovial fluid and anti-inflammatory and chondroprotective effects, was beyond impressive.
The beneficial effects are well studied and documented.
“Specifically, overall pain had decreased by 51%, pain after limb manipulation had decreased by 48%, and pain after physical exertion had decreased by 43% from baseline at 150 days.” (ncbi.nlm.nih.gov)
As a dog parent, I want to ensure that my dog has every possible safe and clinically relevant means available to prevent the development of osteoarthritis and to keep her active happy, and healthy for as long as possible.
Osteoarthritis is a degenerative joint disease that will affect over 20% of all dogs as they age impacting their quality of life and mobility.
That means starting with sound research and adjusting her diet, adding in any scientific-backed dietary supplement and joint supplement, and ensuring she gets enough daily exercise to prevent obesity and keep her joints, ligaments, and muscles in shape.
Diet, or nutrition, physical activity, and fluids play a big role in her and her human parent’s overall health. As a result, we take our dogs’ nutrition very seriously.
Knowing that our dog has a 1 in 5 chance of developing osteoarthritis and already suffered a knee injury at a young age, we are being proactive rather than reactive.
So that brings us to nutrition to start.
Most commercial dog foods are clinically nutritious, however, they often lack key essential vitamins, amino acids, and probiotics.
We completed extensive research on what was the best way to add naturally occurring glucosamine and other joint protecting compounds like chondroitin and hyaluronic acid to her diet.
As we did extensive research on glucosamine and chondroitin, clinical studies rapidly demonstrated that the missing element was hyaluronic acid combined with glucosamine and chondroitin
That brought us to organic, all-natural chicken bone broth which is loaded with natural glucosamine, chondroitin, and packed with other joint protecting compounds like hyaluronic acid.
Chicken bone broth contains proline and hyaluronic acid, which have been shown to reduce the effects of skin aging in human and
animal studies, the hyaluronic acid in chicken bone broth helps with the regulation of water balance in the connective tissues and keeps joints hydrated.
Supplementing your dog’s diet with bone broth could help provide the body with more dietary “conditionally essential” amino acids that are involved in collagen synthesis and healing processes.
Bone broth is a rich, gelatinous substance that offers health benefits that go beyond joint health.
It’s a natural joint supplement and contains the probiotic Lactobacillus which demonstrated a reduction in inflammation to aid in digestive health in preclinical studies.
It prevents dehydration, hydrates, nourishes, and boosts flavor for picky eaters.
Dehydration complicates joint problems, so it’s important to provide fresh, good-quality water in clean bowls at all times.
To encourage a dog to drink more water, add small amounts of organic chicken bone broth to a bowl of water.
This is an easy way to help your dog protect and repair joints, repair cartilage, reduce joint pain, and gain the benefits of natural glucosamine, chondroitin, and hyaluronic acid. The building block of connective tissue and one broth gelatin could be beneficial for your dog’s joint health.
It’s natural liquid health.
In addition, for kibble-fed dogs, adding bone broth to their kibble is beneficial and replaces amino acid lost during the heating process of making kibble.
That means that essential amino acids need to be supplemented in order to meet minimum nutrient requirements and there is not a minimum requirement that pet food companies must meet.
Non-essential amino acids in the diet have been shown to be beneficial to a dog’s overall health, so we mix organic all-natural chicken bone broth to kibble to help make up for the amino acids that their diet is lacking.
Bone broth also adds moisture to kibble, which is beneficial to general health and can help prevent issues such as urinary stones or UTIs.
What is hyaluronic acid?
Hyaluronic acid (HA) is a sugar found naturally in our skin and joints that holds water and helps keep them hydrated. As HA absorbs water, it swells similar to what a hydrogel and humectants do, to prevent the water from evaporating.
HA also works hand in hand with collagen proteins, as HA is also found in joints and skeletal tissues, helping with the retention of collagen.
The role of HA is to work as a lubricant and to help absorb shock in your dog’s joint.
As dogs age, the amount of HA, collagen, and elastin produced by their bodies decreases naturally resulting in joint damage and skin that sags.
Why is hyaluronic acid important?
In a study done by the Animal Science Division of Oeste Paulista University, hyaluronic acid was injected into dogs with hip dysplasia.
The treated group of dogs showed lower Helsinki Chronic Pain Index (HCPI) scores (a), Canine Brief Pain Inventory or pain relief scores, and in the veterinarian evaluation, compared to the Control group.
Of note, was the result that clinical improvement was observed in 100% of the animals in the HA group versus only 50% in the control group regardless of body weight.
Of note was the fact that older dogs showed a clinical improvement including restoration of the elastic and viscous properties of the synovial fluid and anti-inflammatory and chondroprotective effects.
Active Dawg USDA Certified Organic Bone Broth has naturally occurring hyaluronic acid in every tablespoonful.
What is chondroitin?
Chondroitin is a substance that occurs naturally in healthy cartilage — the connective tissue that cushions joints in dogs and people.
Dogs suffering from osteoarthritis experience gradual degeneration of the cartilage that leads to pain, inflammation, and mobility issues.
Chondroitin use in dogs with osteoarthritis
Chondroitin has anti-inflammatory properties and numerous research studies have found that chondroitin appears to increase joint mobility, decrease joint pain, and the need for painkillers.
Chondroitin promotes water retention and elasticity in the cartilage, to ensure shock absorption and adequate nourishment of the tissues that line the joints.
Bottom line, increased mobility means more exercise, stronger muscles and ligaments, and a lower chance of your dog suffering from obesity, which in itself is harmful to joint health.
What is glucosamine?
Glucosamine is a natural compound found in cartilage in joints.
There are several forms of glucosamine — glucosamine sulfate, glucosamine hydrochloride, and N-acetyl glucosamine. These supplements are not interchangeable.
Glucosamine sulfate requires a salt stabilizer and has a 74% purity level. Glucosamine HCl doesn’t have the salt stabilizer and has 99% purity. As a result, glucosamine HCl in a dosage of 1,500 mg equals a dosage of 2,608 mg of glucosamine sulfate.
Glucosamine sulfate: is the most common type of glucosamine used in osteoarthritis supplements. It’s made from the shells of shellfish or synthetically.
Glucosamine hydrochloride: Is also made from shellfish shells, but doesn’t contain the salt stabilizer. It’s far more concentrated than glucosamine sulfate and is recommended for treating osteoarthritis in dogs.
NAG – N-Acetyl-Glucosamine: this form of glucosamine is a derivative of glucose the body’s precursor to hyaluronic acid, which is part of the synovial fluid that lubricates joints. NAG is used for gut health, not for joint repair.
Do Glucosamine and chondroitin have any benefits for dogs with osteoarthritis?
Glucosamine hydrochloride (HCl) and chondroitin sulfate (CS) are commonly recommended natural health products for treating osteoarthritis in dogs.
A study done by the Pharmacy and Pharmaceutical Sciences, University of Alberta, Edmonton, showed that “glucosamine regulates the synthesis of collagen in cartilage and provides mild anti-inflammatory effects while chondroitin sulfate inhibits destructive enzymes in joint fluid and cartilage. The two nutraceuticals also contribute to the synthesis of glycosaminoglycans and proteoglycans, which are building blocks for the formation of cartilage.”
The efficacy of glucosamine sulfate has the greatest efficacy for osteoarthritis due to oral bioavailability (25%-44%). Although Glucosamine sulfate has a higher rate of absorption it is not used with dogs for clinical safety reasons.
The sulfate salt is often stabilized with sodium chloride or potassium chloride which may be harmful to senior dogs who have other health issues such as heart failure, high blood pressure, or renal disease.
Glucosamine and chondroitin often sold together as Glucosamine Chondroitin is recommended by veterinarians as an alternative for treating osteoarthritis in dogs unable to tolerate the adverse effects of non-steroidal anti-inflammatory drugs or NSAIDs. Clinical trials and research have yet to document any real clinical benefit and their use as joint supplements remains questionable and the ability to repair cartilage has yet to be documented.
We also researched fish oil or omega 3 and found that the dosage required for dogs with osteoarthritis is 5,000 mg/day EPA and DHA for a 110 lb dog. That’s equal to 50 capsules of omega-3 daily. The dosages required to treat osteoarthritis, it’s not practical or cost-effective.
Of note and something to keep in mind is nutraceuticals or supplements are not pharmaceuticals; they are considered food by the FDA and regulated as food. This opens things up for contamination and variability in pill to pill dosing since there is no direct regulatory oversight and no requirements for studies to prove efficacy and safety