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Active Dawg is as passionate about the health and fitness of our fur-buddies as our customers are determined to improve the quality of their dogs' life. Through our articles and products, we help dog owners achieve their goals and prevent arthritis, improve gut health, and more.
More so than ever before, people of all ages and from all walks of life are aware of the nutritional need of their dogs and how nutrition impacts their overall health. It's no surprise then that the dog nutrition market worldwide is expected to reach $99 billion by the year 2023!
We take our and our customers dog's health very seriously and only offer the best products that are backed up with scientific data and clinical studies. We're looking to partner up with dog influencers and dog lovers to work together to help make dogs lives better.
Dogs like humans suffer from osteoarthritis and similar joint diseases.
Of the 28 different types of collagen that have been identified, type II collagen is the main structural protein in cartilage.
Joint disorders involving inflammation and cartilage erosion, such as arthritic diseases, are characterized by an autoimmune component in which the immune system acts against the body ’s own type II collagen.
Historically, osteoarthritis (OA) has been characterized as a degenerative, wear-and-tear disease.
However, recent scientific research has identified it as an immunopathological disease – in other words, a disease in which the immune system plays a key role.
That is because, in OA, products from collagen breakdown are recognized by immune cells as potential pathogens and are therefore considered harmful by the body. As a consequence, an inflammatory and cartilage degradation response is activated.
This involves an immune response against endogenous type II collagen, further damaging cartilage in the body.
Native type II collagen and undenatured type II collagen are the same molecule.
Native type II collagen – also known as undenatured or non-hydrolyzed type II collagen
throughout the nutrition industry – is collagen in its biologically active form.
Hydrolyzed collagen – or denatured collagen – is collagen that has been broken down
into smaller peptide molecules.
In its natural form, collagen has a folded triple helix structure consisting of long polypeptide chains. Hydrolyzed collagen is manufactured via a specific hydrolysis process, where enzymes “cut” the triple helix molecule into smaller pieces, i.e. short-chain peptides. This is why hydrolyzed collagen is also known as collagen peptides, or denatured type II collagen.
Native type II collagen on the other hand, is not hydrolyzed and maintains its characteristic three-dimensional structure.
The mechanism by which each collagen acts differs.
Native (undenatured) type II collagen works via an immune-mediated process, known as oral tolerance.
Through this mode of action native type II collagen is recognized by the immune system as an endogenous substance, i.e. naturally occurring in the body, and deactivates the body ’s immune response against its own collagen.
Alternatively, hydrolyzed collagen peptides are highly bioavailable, resulting in a source of the specific amino acids for de novo synthesis of collagen. As such, hydrolyzed collagen peptides act as building blocks to maintain and rebuild cartilage.
The daily dose and intake required for both collagens to be effective in the body varies greatly.
Native (undenatured) type II collagen form is required at doses as low as 40 mg/day for humans, 10 mg/day for dogs.
Active Dawg USDA Certified Organic bone broths are enriched with 10 mg per tablespoon of undenatured Type II collagen.
Meanwhile, the recommendation for hydrolyzed collagen is 10 g/day.
Clinical studies have shown that Native (undenatured) type II Collagen, decrease of collagen destruction, through a mechanism of action of immune mediated oral tolerance.
Whereas, Hydrolyzed collagen – or denatured collagen mechanism of action is anabolic, and increases collagen production. You also need to intake far more, 10 g/day.
Clinical studies show that supplementing native (undenatured) type II collagen can
help to modulate the immune response against endogenous type II collagen, therefore, reducing joint inflammation and cartilage degradation.
Even at the smaller dosages, undenatured Type II Collagen has also been reported to be more effective than the glucosamine and chondroitin sulfate supplements
Thanks to this specific mechanism of action, it takes just a small amount of native type II collagen to support joint health.
This is why the standard dose of ingredients containing native collagen is just 40 mg for humans and 10 mg/day for dogs, once daily, whereas dosages for hydrolyzed collagen can be up to 10 g/day for humans.
The positive immune modulation promoted by native collagen intake – its ability to prevent the immune response against type II collagen produced by the body – has been receiving increasing interest across the scientific community in both veterinary and human studies.
Native (undenatured) type II collagen passes through the stomach and reaches the intestine.
It interacts with the Peyer’s patches in the intestine, which are lymphoid nodules responsible for immune surveillance of the intestinal tract.
It turns off the immune response against endogenous type II collagen
It reduces joint inflammation and cartilage degradation, supporting joint health
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Organic, All-Natural, Healthy, Bowl Lickin' Good!
Active Dawg Bone Broth is USDA Certified organic and all-natural, 100% real chicken. As your pet ages, instead of harsh medications, this gentle broth can provide the healing Collagen peptides and minerals your pet needs. Enriched with Glycosylated Undenatured Type-II Collagen to repair joints and cartilage.
We’re not just another dog supplement company for everyone.
Instead, Active Dawg is designed for parents of 4-legged fur buddies who want the best for their dogs, with an honest and realistic approach.
No matter how old your dog is, we bet that you want a healthy dog with strength, vitality, flexibility, mobility, and longevity.